June 1, 1986Clinical Endocrinology
THE EFFECT OF CHOLINERGIC BLOCKADE ON THE ACTH, β‐ENDORPHIN AND CORTISOL RESPONSES TO INSULIN‐INDUCED HYPOGLYCAEMIA
Why the study?
Does cholinergic blockade with atropine alter ACTH, beta-endorphin, and cortisol responses to insulin-induced hypoglycaemia in healthy male volunteers?
Population
6 healthy male volunteers
Comparison
Cholinergic blockade with atropine during… vs Insulin tolerance test without atropine
Design
RCT, random order
Follow-up
120 minutes
Authors
Discussion
Loading...
Member takes
Implication
Cholinergic blockade facilitates ACTH and beta-endorphin responses to hypoglycemia; extends evidence for parasympathetic modulation of the HPA axis.
Structured PICO
Does cholinergic blockade with atropine alter ACTH, beta-endorphin, and cortisol responses to insulin-induced hypoglycaemia in healthy male volunteers?
P
Population
6 healthy male volunteers
I
Intervention
Cholinergic blockade with atropine during insulin tolerance test
C
Comparator
Insulin tolerance test without atropine
O
Outcome
ACTH, beta-endorphin, and cortisol responses to insulin-induced hypoglycaemiasurrogate
Cholinergic blockade with atropine facilitates ACTH and beta-endorphin responses to insulin-induced hypoglycemia without affecting cortisol levels.
Cite This Study
Evans et al. (1986) studied this question.