Key result
Structural analysis of rotavirus reassortants revealed that interactions between heterologous VP4 and VP7 proteins induce conformational alterations in the VP4 spike that correlate with unexpected phenotypes.
Heterologous interactions between rotavirus outer capsid proteins VP4 and VP7 can alter the conformation of the VP4 spike, explaining the expression of unexpected viral phenotypes in reassortants.
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May explain unexpected rotavirus reassortant phenotypes; leaves open implications for vaccine performance and surveillance.
Pesavento et al. (2003) studied Rotavirus. Rotavirus reassortants vs. Parental rotavirus strains was evaluated on VP4 spike conformation. Structural analysis of rotavirus reassortants revealed that interactions between heterologous VP4 and VP7 proteins induce conformational alterations in the VP4 spike that correlate with unexpected phenotypes.
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