Key result
Group A rotavirus was detected in 15.8% of children under 5 with gastroenteritis in Tunisia, with G1P[8] being the most prevalent strain (41.7%).
Why the study?
The study was conducted to report the molecular characterization of human group A rotaviruses circulating in Tunisia.
Cross-Sectional (n=454)
Yes
In Tunisia, where there is no national anti-rotavirus vaccination strategy, RVAs remain a primary cause of gastroenteritis in children, with G1P[8] and G9P[8] being the most prevalent strains.
Rotavirus remains a cause of pediatric gastroenteritis in unvaccinated Tunisia; supports strain surveillance but leaves open national vaccination policy.
The aim of the present study was to report the molecular characterization of human group A rotaviruses (RVAs) circulating in Tunisia. Stool specimens were collected from children under 5 years of age who had been hospitalized or were consulting for gastroenteritis in Tunisian hospitals between 2015 and 2017. All samples were screened by reverse-transcription polymerase chain reaction (RT-PCR) for the detection of the VP6 gene specific for RVA. RVA-positive samples were further analysed for G/P genotyping by semi-nested multiplex RT-PCR. Among 454 tested samples, 72 (15.8 %) were positive for RVA. G1P[8] was the most prevalent detected strain (41.7%), followed by G9P[8] (32.8%), G2P[4] (7.5%), G12P[8] (7.5%), G1P[6] (3.0%), G2P[8] (1.5%) and G3P[8] (1.5%), with mixed infections in 4.5 % of cases. In the absence of a national anti-rotavirus vaccination strategy, RVAs remain the primary aetiological agent for gastroenteritis in Tunisian children.
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Bennour et al. (2019) conducted a cross-sectional in Gastroenteritis (n=454). Group A rotavirus was evaluated on Detection of group A rotavirus (RVA) and G/P genotyping. Group A rotavirus was detected in 15.8% of children under 5 with gastroenteritis in Tunisia, with G1P[8] being the most prevalent strain (41.7%).
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