Key result
Placement of a novel mechanical circulatory support device in the descending aorta improved pulsatility, facilitated cardiac output, and improved renal perfusion in an in vitro and numerical model.
Why the study?
Does an in-house prototyped mechanical circulatory support pump implanted in the descending aorta improve hemodynamics in simulated congestive heart failure conditions?
Does an in-house prototyped mechanical circulatory support pump implanted in the descending aorta improve hemodynamics in simulated congestive heart failure conditions?
In vitro and numerical simulations suggest that placing a mechanical circulatory support device in the descending aorta improves cardiac output and renal perfusion but may slightly reduce carotid and coronary perfusion.
Requires in vivo validation before trials; leaves open net benefit of descending aortic MCS in heart failure.
Traditional implantation techniques of assist devices from the apex of left ventricle to the ascending or descending aorta are highly invasive and carry substantial complications for end-stage heart failure patients. This study has shown that the descending aorta can be a promising location to install an implantable mechanical circulatory support with minimally invasive surgery. Herein, the hemodynamic effect of an in-house prototyped pump implanted in the descending aorta was investigated numerically as well as experimentally. The objective of the experimental study is met by using the in-house simulator of the cardiovascular loop replicating congestive heart failure conditions. The objective of the numerical study was met by using the modified version of the concentrated lumped parameter model developed by the same team. The results show that the pump placement in the descending aorta can lead to an improvement in pulsatility. The pressure drop, generated at the upstream of the pump, facilitates the cardiac output as a result of after-load reduction, but at the same time, it induces a slight drop in the carotid as well as the coronary perfusion. The pressure rise, generated at the downstream of the pump, improves the blood perfusion in the renal circulation.
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Rezaienia et al. (2015) studied Congestive heart failure. In-house prototyped pump implanted in the descending aorta was evaluated on Hemodynamic effect (pulsatility, pressure drop, cardiac output, perfusion). Placement of a novel mechanical circulatory support device in the descending aorta improved pulsatility, facilitated cardiac output, and improved renal perfusion in an in vitro and numerical model.
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