Key result
Computational fluid dynamics simulations of the Circulite Synergy Micro-pump demonstrated diastolic flow augmentation in the descending aorta but competing flow patterns in the proximal innominate artery during systole.
Why the study?
Does computational fluid dynamics modeling help understand flow patterns in patients with partial mechanical circulatory support?
Case Report (n=2)
Does computational fluid dynamics modeling help understand flow patterns in patients with partial mechanical circulatory support?
Computational fluid dynamics can visualize and quantify complex hemodynamic interactions between native cardiac output and partial mechanical circulatory support devices.
CFD identifies regional flow variations with partial MCS; hypothesis-generating and should not yet alter practice.
Partial mechanical circulatory support represents a new concept for the treatment of advanced heart failure. The Circulite Synergy Micro Pump(®), where the inflow cannula is connected to the left atrium and the outflow cannula to the right subclavian artery, was one of the first devices to introduce this concept to the clinic. Using computational fluid dynamics (CFD) simulations, hemodynamics in the aortic tree was visualized and quantified from computed tomography angiographic (CTA) images in two patients. A realistic computational model was created by integrating flow information from the native heart and from the Circulite device. Diastolic flow augmentation in the descending aorta but competing/antagonizing flow patterns in the proximal innominate artery was observed. Velocity time curves in the ascending aorta correlated well with those in the left common carotid, the left subclavian and the descending aorta but poorly with the one in the innominate. Our results demonstrate that CFD may be useful in providing a better understanding of the main flow patterns in mechanical circulatory support devices.
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Karmonik et al. (2015) conducted a case report in Ischemic cardiomyopathy (n=2). Circulite Synergy Micro-pump was evaluated on Hemodynamics in the aortic tree (velocity, pressure, and wall shear stress). Computational fluid dynamics simulations of the Circulite Synergy Micro-pump demonstrated diastolic flow augmentation in the descending aorta but competing flow patterns in the proximal innominate artery during systole.
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