Key result
Cefamandole prophylaxis was associated with increased warfarin sensitivity early postoperatively, with 14 of 15 hyper-responders having received cefamandole versus 1 receiving vancomycin (p<0.05).
Why the study?
Does cefamandole prophylaxis increase warfarin sensitivity compared to vancomycin in postoperative cardiac valve replacement patients?
Observational (n=60)
Does cefamandole prophylaxis increase warfarin sensitivity compared to vancomycin in postoperative cardiac valve replacement patients?
p-value: p=<0.05
Cefamandole prophylaxis increases warfarin sensitivity early in the postoperative course for cardiac valve replacement patients, potentially leading to excessively high prothrombin times and bleeding risk.
No takes yet. Share an insight, caveat, or question.
May elevate bleeding risk with early warfarin use post-valve replacement; leaves open whether cefamandole should be avoided versus vancomycin.
Angaran et al. (1984) conducted an observational in Postoperative prosthetic cardiac valve (n=60). Cefamandole vs. Vancomycin was evaluated on Hyper-responder status (prothrombin time ≥ 32 sec, 48 hr after initial warfarin dose) (p=<0.05). Cefamandole prophylaxis was associated with increased warfarin sensitivity early postoperatively, with 14 of 15 hyper-responders having received cefamandole versus 1 receiving vancomycin (p<0.05).
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