Key result
In awake cats at rest, the baroceptor reflex effect on cardiac sympathetic nerve activity is larger than on renal sympathetic nerve activity, and this control is modified centrally by atropine.
Why the study?
Does atropine modify the baroceptor reflex control of cardiac and renal sympathetic nerve activity in awake cats?
Population
9 conscious cats (2.2 to 4.5 kg body weight) at rest
Comparison
Atropine followed by norepinephrine to induce… vs Control state
Design
Preclinical
Authors
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Differential baroreflex control of cardiac versus renal sympathetic activity in cats may involve central cholinergic modulation; leaves open translation to human physiology.
Does atropine modify the baroceptor reflex control of cardiac and renal sympathetic nerve activity in awake cats?
In awake cats, the baroceptor reflex effect on cardiac sympathetic nerve activity is larger than on renal sympathetic nerve activity, and this control is centrally modified by atropine.
Ninomiya et al. (1988) studied Healthy awake cats (n=9). Atropine and Norepinephrine vs. Control state (before atropinization) was evaluated on Mean cardiac (MCSNA) and renal sympathetic nerve activity (MRNA) response to MAP changes. In awake cats at rest, the baroceptor reflex effect on cardiac sympathetic nerve activity is larger than on renal sympathetic nerve activity, and this control is modified centrally by atropine.
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