Key result
Adherence to AT9 guidelines for thromboprophylaxis was achieved in only 55.9% of hospitalized patients, with 31.4% receiving overuse and 12.7% underuse of prophylaxis.
Cross-Sectional (n=290)
No
There is a high rate of inappropriate thromboembolic prophylaxis, predominantly overuse, when evaluated against the AT9 guidelines in a tertiary care setting.
Suggests need for local thromboprophylaxis audits to reduce overuse; leaves open whether targeted interventions improve adherence and outcomes.
RATIONALE: Venous thromboembolic disease is a source of significant morbidity in hospitalized patients. The American College of Chest Physicians published the ninth edition of antithrombotic therapy and prevention guidelines (AT9) in 2012, addressing thromboprophylaxis in hospitalized patients. A notable difference from previous guidelines was utilization of risk assessment models for thrombosis and bleeding to classify patients into risk categories. AIM: This study's objective was to evaluate thromboprophylaxis adherence to AT9 guidelines in a population of patients at the Centre intégré universitaire de santé et de service sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke. METHOD: A cross-sectional study at the Centre intégré universitaire de santé et de service sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke was performed between June and December 2012. Patients' risk factors for thrombosis and bleeding, and thromboprophylaxis use were documented. The Padua and Caprini models were used to determine thrombotic risk, and the International Medical Prevention Registry on Venous Thromboembolism bleeding risk score was used for bleeding risk. RESULTS: A total of 290 patients were included for analysis. Overall, 200 patients (70%) received some form of thromboprophylaxis. However, according to AT9 guidelines, only 162 patients (55.9%) received recommended prophylaxis, 91 (31.4%) had overuse of prophylaxis and 37 (12.7%) had underuse of prophylaxis. Appropriate prophylaxis use was higher in surgical (61.8%) than in medical (46.7%) patients. CONCLUSIONS: There was a high rate of inappropriate thromboembolic prophylaxis in our centre according to AT9 guidelines, mostly from overuse of prophylaxis. Utilization of risk assessment models in AT9 guidelines adds to the complexity of physician's decisions to prescribe thromboprophylaxis and needs further validation.
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Thériault et al. (2016) conducted a cross-sectional in Venous thromboembolic disease risk in hospitalized patients (n=290). AT9 guidelines for thromboprophylaxis was evaluated on Adherence to AT9 guidelines (recommended prophylaxis). Adherence to AT9 guidelines for thromboprophylaxis was achieved in only 55.9% of hospitalized patients, with 31.4% receiving overuse and 12.7% underuse of prophylaxis.
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