Key result
Modified-live FCV vaccination induced cellular but not humoral crossimmunity in specified pathogen-free cats against heterologous FCV challenge strains.
Why the study?
Protection against feline calicivirus involves humoral and cellular immunity, but the cellular immune response has not been studied in detail.
Does modified-live FCV F9 vaccination elicit cellular and humoral immunity against heterologous FCV challenges in SPF cats?
Does modified-live FCV F9 vaccination elicit cellular and humoral immunity against heterologous FCV challenges in SPF cats?
Modified-live FCV vaccination induces cellular cross-immunity against heterologous field strains in cats, highlighting the importance of innate and cellular immune mechanisms in FCV defense.
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Cellular cross-immunity may aid FCV defense; leaves open humoral roles and translation beyond SPF cats.
Spiri et al. (2021) studied Feline calicivirus (FCV) infection. Modified-live FCV F9 vaccination vs. Control cats was evaluated on Cellular and humoral immune response. Modified-live FCV vaccination induced cellular but not humoral crossimmunity in specified pathogen-free cats against heterologous FCV challenge strains.
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