Key result
Hemodialysis-induced hypotension was associated with significantly increased plasma dopamine levels, but no significant differences in alpha 1-adrenoceptor function or plasma noradrenaline.
Why the study?
Does postsynaptic alpha-adrenoceptor dysfunction or altered plasma catecholamine levels contribute to hemodialysis-induced hypotension in chronically hemodialyzed patients?
Population
Chronically hemodialyzed patients with and without hemodialysis-induced hypotension
Comparison
Assessment of alpha 1-adrenoceptor function and… vs Patients without hemodialysis-induced hypotension
Design
Cross-sectional
Authors
Loading...
Does not support alpha-adrenoceptor dysfunction in hemodialysis hypotension; hypothesis-generating for dopamine's role and requires prospective confirmation.
Observational
Does postsynaptic alpha-adrenoceptor dysfunction or altered plasma catecholamine levels contribute to hemodialysis-induced hypotension in chronically hemodialyzed patients?
There is no evidence for a pathophysiological role of postsynaptic alpha-adrenoceptor dysfunction in hemodialysis-induced hypotension.
Lübbecke et al. (1990) conducted an observational in Hemodialysis-associated hypotension. Hemodialysis-induced hypotension vs. No hemodialysis-induced hypotension was evaluated on alpha 1-Adrenoceptor function and plasma catecholamine levels. Hemodialysis-induced hypotension was associated with significantly increased plasma dopamine levels, but no significant differences in alpha 1-adrenoceptor function or plasma noradrenaline.
Synapse has enriched one closely related paper. Consider it for comparative context: