Key result
During hemodialysis, plasma norepinephrine levels decreased significantly by 17.4% in patients whose systolic blood pressure increased, but remained stable in those with stable or decreased blood pressure.
Why the study?
How do plasma catecholamine levels correlate with blood pressure changes during hemodialysis in patients with chronic renal insufficiency?
Population
37 patients with chronic renal insufficiency whose primary disease was chronic nephritis, receiving…
Design
Cohort
Follow-up
During a single 4-hour hemodialysis session
Authors
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Norepinephrine decline may associate with intradialytic BP rise; leaves open sympathetic mechanisms in hemodialysis hypertension.
Observational (n=37)
No
How do plasma catecholamine levels correlate with blood pressure changes during hemodialysis in patients with chronic renal insufficiency?
p-value: p=<0.05
Plasma norepinephrine levels tend to decrease in patients whose blood pressure increases during hemodialysis and remain stable in those whose blood pressure is stable or decreases, suggesting sympathetic nervous system activation in response to blood pressure changes.
Tani et al. (1998) conducted an observational in Chronic renal insufficiency on maintenance hemodialysis (n=37). Hemodialysis-induced blood pressure changes vs. Pre-dialysis baseline was evaluated on Plasma norepinephrine (NE) levels at mid-dialysis as a percentage of pre-dialysis levels in the systolic blood pressure increase group (p=<0.05). During hemodialysis, plasma norepinephrine levels decreased significantly by 17.4% in patients whose systolic blood pressure increased, but remained stable in those with stable or decreased blood pressure.
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