Why the study?
Long-term oral anticoagulant therapy complicates the management of urgent surgical conditions or major bleeding.
This narrative review summarizes the current evidence and practical strategies for reversing vitamin K antagonists and direct oral anticoagulants in emergency situations.
Alerts clinicians to tailored reversal options in bleeding; leaves open need for comparative trials of antidotes.
Oral anticoagulants (antivitamin K, direct oral anticoagulants) are routinely prescribed for the prevention or treatment of thromboembolic events, and many patients are now on long-term anticoagulant therapy. However, this complicates the management of urgent surgical conditions or major bleeding. Various strategies have been developed to reverse the anticoagulant effect and this narrative review provides an overview of the wide range of therapies currently available.
No takes yet. Share an insight, caveat, or question.
Foletti et al. (2023) conducted a review in Major bleeding on oral anticoagulants. Anticoagulation reversal strategies was evaluated.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: