Key result
Active systemic lupus erythematosus was associated with a significantly higher relative myocardial T2 ratio compared to inactive disease and healthy controls (2.1 vs 1.8 vs 1.7; P=0.003).
Why the study?
Does a comprehensive cardiovascular magnetic resonance approach detect myocardial involvement and correlate with disease activity in patients with systemic lupus erythematosus?
Population
20 patients with systemic lupus erythematosus and 13 healthy volunteers.
Comparison
Comprehensive cardiovascular magnetic resonance… vs Healthy volunteers and inactive SLE patients.
Design
Cross-sectional
Authors
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Elevated myocardial T2 may flag active cardiac involvement in SLE; hypothesis-generating and should not yet change practice or screening.
Observational (n=33)
Does a comprehensive cardiovascular magnetic resonance approach detect myocardial involvement and correlate with disease activity in patients with systemic lupus erythematosus?
Absolute Event Rate: 2.1% vs 1.7%
p-value: p=0.003
A comprehensive CMR approach combining T2-weighted, early, and late enhancement imaging can detect myocardial involvement in SLE, which correlates with disease activity.
Abdel‐Aty et al. (2008) conducted an observational in Systemic lupus erythematosus (n=33). Active systemic lupus erythematosus vs. Inactive systemic lupus erythematosus and healthy volunteers was evaluated on Relative T2 ratio (myocardium to skeletal muscle) (p=0.003). Active systemic lupus erythematosus was associated with a significantly higher relative myocardial T2 ratio compared to inactive disease and healthy controls (2.1 vs 1.8 vs 1.7; P=0.003).
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