Key result
Pregnancy altered the phosphorylation state of IGFBP-1, significantly increasing levels measured by RIA 6305 to 37, 51, and 83 micrograms/L across trimesters compared to controls (P<0.0005).
Population
Normal subjects and pregnant women (plasma and amniotic fluid samples)
Design
Other
Authors
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No immediate clinical implications; leaves open whether IGFBP-1 phosphorylation changes affect fetal growth.
Observational
p-value: p=<0.0005
The phosphorylation state of IGFBP-1 changes during pregnancy, which may influence IGF bioavailability and fetal growth.
Westwood et al. (1994) conducted an observational in Pregnancy. Pregnancy vs. Normal subjects was evaluated on IGFBP-1 levels measured by RIA 6305 (p=<0.0005). Pregnancy altered the phosphorylation state of IGFBP-1, significantly increasing levels measured by RIA 6305 to 37, 51, and 83 micrograms/L across trimesters compared to controls (P<0.0005).
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