What question did this study set out to answer?

To determine whether the high rate of clinical treatment failures in Indian kala-azar is caused by infection with antimony-resistant strains of Leishmania donovani.

August 1, 1999The Journal of Infectious Diseases

Evidence that the High Incidence of Treatment Failures in Indian Kala‐Azar Is Due to the Emergence of Antimony‐Resistant Strains ofLeishmania donovani

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Authors

RLRosalía LiraMexican Social Security Institute SSShyam SundarNIMS University AMAnand MakhariaInstitute of Medical Sciences

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Implication

Observational study reveals antimony resistance in Leishmania donovani isolates from unresponsive visceral leishmaniasis patients, indicating parasite-driven treatment failure.

Key Points

To determine whether the high rate of clinical treatment failures in Indian kala-azar is caused by infection with antimony-resistant strains of Leishmania donovani.
Isolated Leishmania donovani from splenic aspiration smears of 24 patients in Bihar, India, comprising 15 non-responders and 9 responders to sodium antimony gluconate (SAG).
Tested in vitro SAG susceptibility across both the intracellular amastigote and extracellular promastigote stages of each isolate.
Clinical treatment failure correlated strongly with in vitro SAG resistance in intracellular amastigotes (P < .001), with unresponsive isolates showing higher mean inhibitory values (ED50 = 7.4 ± 3.7 vs. 2.4 ± 2.6 µg/mL; ED90 = 29.1 ± 11.1 vs. 6.4 ± 7.8 µg/mL).
Extracellular promastigote assays demonstrated no correlation with clinical response (ED50 = 52 ± 29 µg/mL for unresponsive vs. 48 ± 22 µg/mL for responsive isolates).

Cite This Study

Lira et al. (1999) studied this question.

synapsesocial.com/papers/6a99d162f62e746e5845a2dd https://doi.org/10.1086/314896

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Implication

Observational study reveals antimony resistance in Leishmania donovani isolates from unresponsive visceral leishmaniasis patients, indicating parasite-driven treatment failure.

Evidence that the High Incidence of Treatment Failures in Indian Kala‐Azar Is Due to the Emergence of Antimony‐Resistant Strains ofLeishmania donovani

Discussion

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Implication

Key Points

Cite This Study

Evidence that the High Incidence of Treatment Failures in Indian Kala‐Azar Is Due to the Emergence of Antimony‐Resistant Strains ofLeishmania donovani

Discussion

Member takes

Implication

Key Points

Cite This Study

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