Key result
Anti-beta2-glycoprotein I antibodies were significantly more prevalent in children with SLE and neuropsychiatric disease compared to those without (P=0.02).
Why the study?
Are antiphospholipid antibodies associated with neuropsychiatric manifestations in children with systemic lupus erythematosus?
Cohort (n=137)
No
Are antiphospholipid antibodies associated with neuropsychiatric manifestations in children with systemic lupus erythematosus?
p-value: p=0.02
In children with SLE, anti-beta(2)GPI antibodies are associated with neuropsychiatric disease, while lupus anticoagulant is associated with cerebrovascular disease and chorea.
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May inform neuropsychiatric risk stratification in pediatric SLE; hypothesis-generating and requires prospective validation before practice change.
Avčin et al. (2008) conducted a cohort in Systemic lupus erythematosus (SLE) (n=137). Antiphospholipid antibodies (aCL, anti-beta2GPI, LAC) vs. Absence of antiphospholipid antibodies was evaluated on Association of antiphospholipid antibodies with neuropsychiatric manifestations (p=0.02). Anti-beta2-glycoprotein I antibodies were significantly more prevalent in children with SLE and neuropsychiatric disease compared to those without (P=0.02).
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