Severe reversible cardiac failure after bortezomib treatment combined with chemotherapy in a non-small cell lung cancer patient: a case report
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Key result
Treatment with bortezomib combined with cisplatin and gemcitabine induced severe but reversible congestive cardiac failure in a 53-year-old lung cancer patient with subclinical baseline cardiomyopathy.
Population
1 patient, 53-year-old male with stage IIIB squamous cell carcinoma of the lung, heavy smoker with a history…
Design
Case_report
Follow-up
11 months
Authors
Discussion
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Overview
May support cardiac monitoring in subclinical cardiomyopathy on bortezomib regimens; hypothesis-generating and requires prospective confirmation.
Study Design
Type
Case Report (n=1)
Structured PICO
P
Population
A 53-year-old male with stage IIIB squamous cell carcinoma of the lung and no prior cardiac history who developed severe heart failure during experimental treatment.
I
Intervention
Bortezomib 1.0 mg/m2 on days 1 and 8, combined with cisplatin 70 mg/m2 on day 1 and gemcitabine 1000 mg/m2 on days 1 and 8 (3-week cycles) for 4 cycles.
O
Outcome
Development of severe, reversible congestive cardiac failuresafety
Bortezomib treatment may induce severe but reversible congestive cardiac failure, highlighting the need for careful cardiac monitoring in patients with pre-existing subclinical left ventricular dysfunction.
Limitations
- Single case report
- Retrospective measurement of baseline NT-proBNP
- Lack of baseline LVEF measurement
- Confounding effect of cisplatin-hydration
Cite This Study
Voortman et al. (2006) conducted a case report in Non-small cell lung cancer (n=1). Bortezomib combined with cisplatin and gemcitabine was evaluated on Development of congestive cardiac failure. Treatment with bortezomib combined with cisplatin and gemcitabine induced severe but reversible congestive cardiac failure in a 53-year-old lung cancer patient with subclinical baseline cardiomyopathy.
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