Key result
Transient myocardial ischemia induced by dipyridamole (positive SPECT) significantly increased plasma hydrogen peroxide levels from 30.5 to 50.3 µmol/L (P=0.004).
Why the study?
Does transient myocardial ischemia induced by dipyridamole stress testing increase plasma hydrogen peroxide levels in patients evaluated for coronary heart disease?
Population
53 patients (37 men and 16 women, mean age 49 +/- 11 years) evaluated for coronary heart disease.
Comparison
Dipyridamole stress test followed by… vs Before vs after dipyridamole infusion, and…
Design
Cross-sectional
Follow-up
Immediately after drug infusion
Authors
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Dipyridamole-induced ischemia was associated with higher hydrogen peroxide; hypothesis-generating for oxidative stress in CAD, needs prospective confirmation before clinical relevance.
Observational (n=53)
Does transient myocardial ischemia induced by dipyridamole stress testing increase plasma hydrogen peroxide levels in patients evaluated for coronary heart disease?
Absolute Event Rate: 50.3% vs 21%
p-value: p=0.004
Transient myocardial ischemia induced by dipyridamole stress testing generates toxic oxygen derivatives, specifically increasing plasma hydrogen peroxide levels.
Kaźmierczak et al. (1995) conducted an observational in Suspected coronary artery disease (n=53). Transient myocardial ischemia (positive SPECT test) vs. Negative SPECT test was evaluated on Hydrogen peroxide plasma levels after dipyridamole infusion (p=0.004). Transient myocardial ischemia induced by dipyridamole (positive SPECT) significantly increased plasma hydrogen peroxide levels from 30.5 to 50.3 µmol/L (P=0.004).
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