What is the clinical evidence from this study?

Study design: Other. Population: Normal coronary artery (n=10). Intervention: Adenosine triphosphate (ATP) vs. Adenosine. Primary outcome: Coronary flow reserve (CFR), time to maximum effect (Tmax), and time to baseline (TBL).

What question did this study set out to answer?

To compare coronary artery vasomotion, coronary flow reserve, and response times following the infusion of adenosine triphosphate versus adenosine.

January 1, 1998Sunhwan'gi

Assessment of Coronary Flow Reserve with Adenosine Triphosphate Compared to the Response to Adenosine

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Key result

Adenosine triphosphate achieved maximum vasodilation faster than adenosine in patients with normal coronary arteries, with a similar side effect profile.

Why the study?

Does adenosine triphosphate infusion provide comparable coronary vasomotion to adenosine infusion in patients with normal coronary arteries?

Population

10 patients with normal coronary arteries, mean age 57±11 years, 6 male and 4 female.

Comparison

Adenosine triphosphate (ATP) infusion vs Adenosine infusion

Design

Cohort

Authors

WKWon KimUlsan College STSeung-Jea Takh HKHan‐Soo KimGriffith University

Discussion

Member takes

Implication

ATP may shorten time to maximal vasodilation in coronary testing; leaves open diagnostic equivalence and requires randomized validation.

Key Points

To compare coronary artery vasomotion, coronary flow reserve, and response times following the infusion of adenosine triphosphate versus adenosine.
Evaluated 10 patients with normal coronary arteries (6 male, 4 female; mean age 57 ± 11 years, range 41–74).
Administered infusions of adenosine triphosphate and adenosine while measuring coronary flow reserve, time to maximum effect, and time to baseline in the left anterior descending and right coronary arteries.
Adenosine triphosphate achieved time to maximum effect earlier than adenosine, demonstrating faster onset of maximal coronary vasodilation.
Mild chest pain occurred in 2 patients with adenosine triphosphate and 2 patients with adenosine, showing an identical adverse event occurrence.

Structured PICO

Does adenosine triphosphate infusion provide comparable coronary vasomotion to adenosine infusion in patients with normal coronary arteries?

Population

10 patients with normal coronary arteries, aged 41 to 74 years, studied for coronary flow reserve during ATP and adenosine infusion.

Intervention

Adenosine triphosphate (ATP) infusion

Comparator

Adenosine infusion

Outcome

Coronary flow reserve (CFR), time to maximum effect (Tmax), and time to baseline (TBL) in coronary arterysurrogate

Adenosine triphosphate provides comparable coronary vasodilation to adenosine but achieves its maximum effect faster, suggesting it is a safe and effective alternative for pharmacological stress testing.

Cite This Study

Kim et al. (1998) studied Normal coronary artery (n=10). Adenosine triphosphate (ATP) vs. Adenosine was evaluated on Coronary flow reserve (CFR), time to maximum effect (Tmax), and time to baseline (TBL). Adenosine triphosphate achieved maximum vasodilation faster than adenosine in patients with normal coronary arteries, with a similar side effect profile.

synapsesocial.com/papers/6a99d2ffa0b5ff9fb7fa4fe4 https://doi.org/10.4070/kcj.1998.28.6.863

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Assessment of Coronary Flow Reserve with Adenosine Triphosphate Compared to the Response to Adenosine

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Assessment of Coronary Flow Reserve with Adenosine Triphosphate Compared to the Response to Adenosine

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider