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The complement-fixation inhibition test (CFI) was evaluated as a means to detect antibodies in cat sera to feline oncornavirus antigens. Antibody titers ranged from 1 :4 to >1 :256 in sera from neoplastic and normal cats. In contrast, antibodies were not detected in sera from germfree, clinically normal cats. The CFI antibody would not fix guinea pig or feline complement in direct CF tests and would not agglutinate tanned sheep red blood cells coated with feline leukemia virus (FeLV) antigen. Weak precipitin activity with FeLV antigen was detected in CFI positive sera. The specificity of the CFI test was confirmed by demonstration that serum titers were inversely proportional to FeLV antigen concentration. Means to define the specificities of the noncomplement-fixing feline antibodies for individual feline oncornavirus antigen were discussed.
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Olsen et al. (1972) studied this question.
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