Key result
Selective inhibition of RNase H activity with NaF had no detectable effect on the size, structure, or genetic complexity of the DNA product synthesized by RSV RNA-directed DNA polymerase.
Inhibition of RNase H activity with NaF does not affect the size, structure, genetic complexity, or displacement of DNA synthesized by RSV RNA-directed DNA polymerase in vitro.
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RNase H inhibition leaves RSV DNA synthesis unaltered in vitro; leaves open its necessity in viral replication and requires in vivo confirmation.
Collett et al. (1976) studied this question. Selective inhibition of RNase H activity with NaF was evaluated on Effect on the size, structure, or genetic complexity of the DNA product synthesized, and displacement of DNA from 70S RNA:DNA hybrid structures. Selective inhibition of RNase H activity with NaF had no detectable effect on the size, structure, or genetic complexity of the DNA product synthesized by RSV RNA-directed DNA polymerase.
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