Key result
Microinjection of blocking anti-AE1 antibodies decreased the rate of anion exchange by 79%, indicating that a novel AE1 splicoform (nAE1) mediates cardiac Cl-/HCO3- exchange.
Population
Isolated neonatal and adult rat cardiomyocytes
Design
Preclinical
Authors
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nAE1 mediates cardiac Cl-/HCO3- exchange in rats; leaves open its role in human heart disease and therapeutic targeting.
Effect estimate: 79% decrease
A novel spliced variant of the AE1 gene (nAE1) is the predominant anion exchanger mediating Cl-/HCO3- exchange in rat ventricular myocytes.
Richards et al. (1999) studied Healthy. Anti-AE1 antibodies microinjection vs. Rabbit IgG or antibodies preincubated with immunizing peptides was evaluated on Cl-/HCO3- exchange activity (79% decrease). Microinjection of blocking anti-AE1 antibodies decreased the rate of anion exchange by 79%, indicating that a novel AE1 splicoform (nAE1) mediates cardiac Cl-/HCO3- exchange.
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