Key result
hnRNP-U enhances the expression of specific genes, including tumor necrosis factor alpha, GADD45A, HEXIM1, HOXA2, IER3, NHLH2, and ZFY, by binding to and stabilizing their mRNAs.
hnRNP-U plays a role in regulating gene expression by binding to and stabilizing specific mRNAs, including TNF-alpha.
May implicate hnRNP-U in cardiac inflammatory gene control; leaves open human relevance and therapeutic potential.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are thought to be involved in pre-mRNA processing. hnRNP-U, also termed scaffold attachment factor A (SAF-A), binds to pre-mRNA and nuclear matrix/scaffold attachment region DNA elements. However, its role in the regulation of gene expression is as yet poorly understood. In the present study, we show that hnRNP-U specifically enhances the expression of tumor necrosis factor alpha mRNA by increasing its stability, possibly through binding to the 3' untranslated region. We also show that hnRNP-U enhances the expression of several other genes as well, including GADD45A, HEXIM1, HOXA2, IER3, NHLH2, and ZFY, by binding to and stabilizing these mRNAs. These results suggest that hnRNP-U enhances the expression of specific genes by regulating mRNA stability.
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Yugami et al. (2006) studied this question. hnRNP-U was evaluated on Gene expression and mRNA stability. hnRNP-U enhances the expression of specific genes, including tumor necrosis factor alpha, GADD45A, HEXIM1, HOXA2, IER3, NHLH2, and ZFY, by binding to and stabilizing their mRNAs.
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