Key result
Multiple sclerosis is a neurologic disability caused by focal destruction of myelin in the CNS, often beginning in the fourth decade of life, and may result from early-life viral infection.
Multiple sclerosis is a neurologic disability in adults characterized by focal destruction of myelin in the CNS, often diagnosed with elevated CSF gamma globulin.
Alerts clinicians to typical MS onset and possible viral etiology; leaves open causal confirmation in prospective studies.
Multiple sclerosis (MS), a common cause of neurologic disability in adults, most often begins in the early part of the fourth decade of life. Signs and symptoms are the result of focal destruction of myelin in the CNS. An elevated CSF gamma globulin level or evidence of an oligoclonal CSF gamma globulin is helpful in diagnosis. MS may be an uncommon result of early-life viral infection in genetically susceptible persons.
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Donald H. Silberberg (1978) conducted a review in Multiple sclerosis. Multiple sclerosis is a neurologic disability caused by focal destruction of myelin in the CNS, often beginning in the fourth decade of life, and may result from early-life viral infection.
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