Why the study?
Does carotid angioplasty and stenting improve outcomes compared to carotid endarterectomy in patients with carotid artery stenosis?
Does carotid angioplasty and stenting improve outcomes compared to carotid endarterectomy in patients with carotid artery stenosis?
Carotid angioplasty and stenting are emerging alternatives to endarterectomy, particularly in high-risk surgical patients, though results from major randomized trials are still pending.
Carotid endarterectomy is a well-established treatment of improving the carotid luminal diameter and preventing strokes, and the indications and complications are well-defined. Carotid angioplasty and stent placements are relatively newer ways of treating carotid artery stenosis. In certain contexts, they may have some advantages over carotid endarterectomy. However, the success rates, morbidity, and mortality associated with these procedures are less well characterized. In earlier comparative studies, the incidence of ipsilateral stroke rate was higher with angioplasty, but in later studies, this trend is reversing. Angioplasty may also have an edge in specific situations like patients with coexisting significant coronary arterial disease, contralateral carotid artery occlusion, and in instances when the narrowing is long and at multiple sites. Protective devices like distal occlusion balloon and filter protection devices may reduce the incidence of stroke. We are still awaiting the results of some major randomized head-to-head trials comparing carotid endarterectomy and stenting.
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Mathew et al. (2005) conducted a review in Carotid artery stenosis. Carotid angioplasty and stent placements vs. Carotid endarterectomy was evaluated. Carotid angioplasty and stenting are emerging alternatives to carotid endarterectomy for carotid artery stenosis, though definitive comparative efficacy awaits results from major randomized trials.
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