Key result
Coronary thrombolysis reduces mortality in women with acute myocardial infarction, though absolute benefit may be less than in men and bleeding complications may be more common.
Why the study?
Does coronary thrombolysis improve outcomes and what are the risks in women with acute myocardial infarction?
Does coronary thrombolysis improve outcomes and what are the risks in women with acute myocardial infarction?
Coronary thrombolysis is effective in women with AMI, but clinicians should be aware of potentially reduced absolute benefit and increased bleeding risks, especially in older women.
Answers are grounded in this paper and cite their sources.
Supports awareness of sex-specific risks with thrombolysis in AMI; leaves open need for updated sex-specific trials.
Acute myocardial infarction (AMI) is a major cause of morbidity and mortality throughout the world. Although the incidence of AMI is higher in men than women, it is responsible for more than 250,000 annual deaths among women within the United States alone. Coronary thrombolysis is the treatment of choice for AMI and reduces mortality rates in both men and women. However, the absolute benefit may be less in women and, in addition, may not be maintained beyond the early postinfarction period. Bleeding complications, including intracranial hemorrhage, may be more common in women, particularly those more than 65 years of age. The author reviews the topic of coronary thrombolysis in women.
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Richard C. Becker (2008) conducted a review in Acute myocardial infarction. Coronary thrombolysis was evaluated. Coronary thrombolysis reduces mortality in women with acute myocardial infarction, though absolute benefit may be less than in men and bleeding complications may be more common.
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