Key result
A low fibrillatory wave amplitude on surface ECG independently predicted a higher rate of atrial tachyarrhythmia recurrence after catheter ablation.
Why the study?
Fibrillatory wave amplitude during AF is thought to reflect structural atrial remodeling, but what determines it remains unclear.
Does low fibrillatory wave amplitude predict recurrence of atrial tachyarrhythmias after catheter ablation in patients with atrial fibrillation?
Cohort (n=114)
No
Does low fibrillatory wave amplitude predict recurrence of atrial tachyarrhythmias after catheter ablation in patients with atrial fibrillation?
Automated measurement of fibrillatory wave amplitude independently predicts arrhythmia recurrence after atrial fibrillation ablation, regardless of the degree of left atrial structural remodeling.
Answers are grounded in this paper and cite their sources.
FWA may refine pre-ablation recurrence risk stratification; hypothesis-generating pending prospective validation.
BACKGROUND: The fibrillatory wave amplitude (FWA) during atrial fibrillation (AF) is thought to reflect structural atrial remodeling, but it remains unclear what determines the FWA. METHODS: 114 consecutive patients were prospectively studied who underwent catheter ablation of AF. The mean FWA was computed by automated surface ECG analyses. The extent of the left atrial (LA) voltage-defined atrial fibrosis and conduction properties were estimated by a three-dimensional high-density electroanatomical mapping system. The LA size was evaluated by transthoracic echocardiography. The study patients were divided into 2 groups according to an FWA in lead V1 above the median value of 46 µV (high FWA group, n=57) or below 46 µV (low FWA group, n=57). RESULTS: There were no differences in the age, gender, CHADS2 score, prevalence of paroxysmal AF, medications, ablation strategy, and LA volume index between the two groups. The LA low voltage areas in the low FWA group were not different from those in the high FWA group. The total LA activation time and local LA conduction velocity did not differ between the two groups. During a median follow-up of 710 days, the recurrence rate after ablation was significantly higher in patients with a low FWA than a high FWA (log-rank P=0.02). In a multivariate analysis, non-paroxysmal AF, the LA volume index, and FWA were independent predictors of recurrence after ablation. CONCLUSIONS: The FWA was not correlated with the markers of atrial structural remodeling. Nevertheless, the FWA could still provide information for predicting the clinical outcome after AF ablation.
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Ishihara et al. (2022) conducted a cohort in Atrial fibrillation (n=114). Low fibrillatory wave amplitude (FWA < 46 µV) vs. High fibrillatory wave amplitude (FWA ≥ 46 µV) was evaluated on Recurrence-free survival from atrial tachyarrhythmias (HR 0.975, 95% CI 0.955-0.993, p=< 0.01). A low fibrillatory wave amplitude on surface ECG independently predicted a higher rate of atrial tachyarrhythmia recurrence after catheter ablation.
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