Key result
Lead V5 fibrillatory wave amplitude strongly correlates with healthy LA tissue, marking viable atrial myocytes.
Why the study?
Fibrillatory wave amplitude (FWA) predicts catheter ablation outcome and has been described as a non-invasive marker of AF complexity, but its actual determinants remain incompletely understood.
Observational (n=29)
Effect estimate: R = 0.786
p-value: p=<0.001
Fibrillatory Wave Amplitude is mainly determined by the amount of viable atrial myocytes rather than AF complexity, serving as a marker of atrial tissue pathology.
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FWA in V5 may non-invasively mark viable atrial tissue in AF; hypothesis-generating and requires prospective validation before clinical use.
Squara et al. (2022) conducted an observational in Persistent Atrial Fibrillation (n=29). Radiofrequency catheter ablation was evaluated on Correlation of FWA in V5 with the surface of healthy left atrial tissue (R = 0.786, p=<0.001). Fibrillatory wave amplitude in lead V5 strongly correlated with the surface of healthy left atrial tissue (R=0.786; p<0.001), suggesting it is a marker of viable atrial myocytes.
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