Key result
Serum creatine kinase activity in rodent exercise myopathy is an inadequate indicator of muscle injury both quantitatively and qualitatively, as it may increase without concomitant muscle damage.
Authors
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Urges caution interpreting CK as injury marker in rodent exercise models; leaves open need for histologic validation in preclinical studies.
Komulainen et al. (1995) studied Exercise-induced muscle damage. Exercise protocols (swimming, running, or combination) vs. Separate protocols was evaluated on Serum creatine kinase activity and beta-glucuronidase activity. Serum creatine kinase activity in rodent exercise myopathy is an inadequate indicator of muscle injury both quantitatively and qualitatively, as it may increase without concomitant muscle damage.
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