Key result
The MTP -493 T-substitution was significantly associated with an increased risk of NAFLD (OR 2.91), while women under 50 years of age demonstrated a lower prevalence of NAFLD compared to men.
Why the study?
The frequency, gender-specific differences, and impact of polymorphisms in NAFLD among the population of Kerala State, South India needed investigation.
Do gender and the MTP -493 G/T polymorphism affect the prevalence and clinical profile of NAFLD in a South Indian population?
Cross-Sectional (n=363)
No
Do gender and the MTP -493 G/T polymorphism affect the prevalence and clinical profile of NAFLD in a South Indian population?
Women under 50 years of age in South India have a lower prevalence of NAFLD despite a higher frequency of the MTP -493 T-allele mutation, suggesting a potential protective role of estrogens against genetic and metabolic predispositions.
Answers are grounded in this paper and cite their sources.
MTP -493 T-allele may increase NAFLD risk in South Indians; hypothesis-generating for estrogen protection in women under 50, needing prospective validation.
Aim To investigate frequency, gender-specific differences and impact of polymorphisms in Non alcoholic Fatty Liver Disease (NAFLD) among the population of Kerala State, South India with a high incidence of type 2 Diabetes Mellitus (Type 2 DM). Methods In a Community based study, data were collected on anthropometry, blood pressure, morbidity patterns and Ultrasound was carried out in 484 subjects. 121 subjects were excluded due to other findings on ultrasonography, hepatitis B and C. 363 subjects, 126 with NAFLD (cases) and 237 with no NAFLD (controls) were evaluated. Blood samples collected after 12 hours fasting were analysed for blood glucose, Liver Function Tests, Lipid profile and Genetic studies for MTP polymorphisms. Results A low prevalence of NAFLD was noted in women below the age of 50 years (P<0.05). Prevalence of Type 2 DM was 14% and more common in men (P=0.002). Mean BMI was 25.5 for the NAFLD group and 23.2 for controls (p< 0.001). Women with NAFLD had higher BMI (P=0.003), systolic blood pressure (SBP) (P=0.030), LDL (P=0.001), HDL (P=0.001) and alkaline phosphatase (P<0.001) than men with NAFLD. Women with NAFLD had increased total cholesterol, higher AST/ALT ratio, (P<0.001) and diastolic BP (P=0.061) compared to women controls. Microsomal triglyceride transfer protein (MTP) T-substitution at -493 was significantly more common in NAFLD than controls (P=0.003). High prevalence was noted among females as carriers (P=0.002). More than 80% of the T-allele carriers were females in the 20-50 years of age group, compared to 25% among males. Conclusion Women under 50 years of age had less NAFLD but more often had type 2 DM, metabolic syndrome, high BMI and the MTP -493 mutation.. The specific age cut-off, for differences, indicates that estrogens may play an important role.
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Shenoy et al. (2020) conducted a cross-sectional in Non-alcoholic fatty liver disease (NAFLD) (n=363). MTP -493 T-substitution vs. Non-carriers (G/G genotype) was evaluated on Presence of NAFLD (OR 2.91, 95% CI 1.42-5.94, p=0.003). The MTP -493 T-substitution was significantly associated with an increased risk of NAFLD (OR 2.91), while women under 50 years of age demonstrated a lower prevalence of NAFLD compared to men.
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