Key result
Relaxation interventions significantly decreased salivary alpha-amylase activity in perioperative breast cancer patients, which correlated with reduced anxiety and pain but not sympathetic nervous system activity.
Why the study?
Does relaxation reduce salivary alpha-amylase activity as a marker of stress in perioperative breast cancer patients?
Observational (n=75)
Yes
Does relaxation reduce salivary alpha-amylase activity as a marker of stress in perioperative breast cancer patients?
p-value: p=<0.05
Salivary alpha-amylase activity decreases with relaxation in perioperative patients, serving as a potential non-invasive marker for relaxation response, though it does not strongly correlate with sympathetic nervous system activity.
May support salivary alpha-amylase as a perioperative stress marker in breast cancer; hypothesis-generating pending randomized confirmation.
The psychological stress of most perioperative patients has been reduced by many interventions. In order to evaluate the effects of these interventions, biomarkers are being considered as objective assessment tools in addition to the subjective assessment tools. It has been thought that salivary α-amylase (sAA) activity is associated with sympathetic nervous system activity, which reflects psychological stress. We examined the relationship between sAA, self-reported data, and autonomic nervous system activity to assess the reliability of sAA as a marker for relaxing response in surgery-related stress. The sAA, the State anxiety, Visual Analogue Scale (VAS) of pain, and heart rate variability were used to assess prior to and after the relaxation on the day before surgery, and on postoperative days (POD) 1, 2, 3, and 7. A total of 75 patients participated and 301 relaxing response readings were obtained. We found that the sAA significantly decreased depending upon the pain and anxiety by relaxation, but they were unrelated to sympathetic nervous system activity. There was weak correlation between the change in sAA, and anxiety and VAS pain. Thus, sAA appears to be an easy-to-use, non-invasive and good marker for relaxing response within a short period in surgery-related stress patients.
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Minowa et al. (2012) conducted an observational in Perioperative psychological stress in breast cancer (n=75). Relaxation (rest with eyes closed or listening to CD) vs. Pre-relaxation baseline was evaluated on Change in salivary alpha-amylase (sAA) activity (p=<0.05). Relaxation interventions significantly decreased salivary alpha-amylase activity in perioperative breast cancer patients, which correlated with reduced anxiety and pain but not sympathetic nervous system activity.
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