Key result
Surgical excision of epicardial adipose tissue attenuated the progression of coronary atherosclerosis, with plaque length in the resected middle LAD segment not significantly increasing (p>0.05) unlike adjacent unperturbed segments (p<0.01).
Why the study?
Does surgical excision of coronary epicardial adipose tissue reduce the progression of coronary atherosclerosis in a pig model?
Population
18 Ossabaw miniature swine.
Comparison
Surgical excision of a 15 mm length by 3-5 mm… vs Proximal and distal LAD segments within the same…
Design
Preclinical, Blinded image analysis.
Follow-up
3 months
Authors
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Local epicardial fat excision attenuates atherosclerosis progression in pigs; leaves open translation to human coronary disease.
Does surgical excision of coronary epicardial adipose tissue reduce the progression of coronary atherosclerosis in a pig model?
Absolute Event Rate: 7.64% vs 8.24%
p-value: p=>0.05
Surgical excision of epicardial adipose tissue in a porcine model attenuated the local progression of coronary atherosclerosis, suggesting a direct pro-atherogenic role of epicardial fat.
McKenney et al. (2014) studied Coronary atherosclerosis (n=18). Selective coronary adipectomy vs. Adjacent unperturbed coronary segments (proximal and distal LAD) was evaluated on Circumferential plaque length progression (p=>0.05). Surgical excision of epicardial adipose tissue attenuated the progression of coronary atherosclerosis, with plaque length in the resected middle LAD segment not significantly increasing (p>0.05) unlike adjacent unperturbed segments (p<0.01).
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