Key result
Heart rate variability indices were moderately depressed in children with atrial septal defect and negatively correlated with mean right atrial and end-diastolic right ventricular pressures.
Why the study?
How does heart rate variability behave and correlate with hemodynamic parameters in children with atrial septal defect?
Observational (n=20)
How does heart rate variability behave and correlate with hemodynamic parameters in children with atrial septal defect?
Heart rate variability is moderately depressed in children with atrial septal defect and correlates negatively with right ventricular filling pressures, highlighting the role of these pressures in autonomic control.
The aim of this study was to assess heart rate variability, a noninvasive parameter for studying the neurohumoral control of heart rate, in children with atrial septal defect. We examined five time-domain and three frequency-domain indices of heart rate variability determined from 24-hour Holter recordings in 20 children, aged 3-14 years, with secundum atrial septal defect who were about to undergo operation. The measures were compared to normal ranges and to the hemodynamic data of the preoperative cardiac catheterization. Most indices of heart rate variability were moderately depressed in children with atrial septal defect. Our data revealed negative correlations between indices and the mean right atrial pressure and the enddiastolic right ventricular pressure, respectively. The study demonstrates the importance of the right ventricular filling pressures for the autonomic control of the heart in children with atrial septal defect.
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Massin et al. (1998) conducted an observational in Secundum atrial septal defect (n=20). Secundum atrial septal defect vs. Normal ranges was evaluated on Heart rate variability indices. Heart rate variability indices were moderately depressed in children with atrial septal defect and negatively correlated with mean right atrial and end-diastolic right ventricular pressures.
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