What question did this study set out to answer?

To characterize dynamic changes in circulating lymphocyte subsets after severe physical trauma and evaluate their association with infectious complications and mortality.

December 1, 1993Journal of Trauma and Acute Care Surgery

Lymphocyte Subset Responses to Trauma and Sepsis

View Full Paper

Ask AI

Bookmark

To characterize dynamic changes in circulating lymphocyte subsets after severe physical trauma and evaluate their association with infectious complications and mortality.
Followed 105 trauma patients (Injury Severity Score ≥ 20) across three trauma centers throughout hospitalization, stratified into uninfected recovery (n = 64), major infection (n = 26), and deceased (n = 15; 7 with sepsis).
Quantitated total lymphocytes, pan-T (CD2), helper T (CD4), suppressor T (CD8), pan-B (CD20), and DR-expressing cells using monoclonal antibodies and flow cytometric analysis.
Significant lymphopenia peaked at 3 days post-injury compared to controls (p < 0.05), recovering gradually over the hospital course.
A hierarchical reduction across outcome groups showed the lowest absolute numbers of CD4 helper and CD8 suppressor T cells in patients who subsequently developed infections or died.
The helper-to-suppressor (CD4/CD8) ratio did not differ significantly across the three outcome cohorts despite profound total subset depletion.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Multicenter cohort study reveals severe early post-injury lymphopenia in major trauma patients, indicating that profound T-cell depletion correlates with subsequent infection and mortality risk.

Cite This Study

Cheadle et al. (1993) studied this question.

synapsesocial.com/papers/6a99ed8a6ce0f2d359b4fa34 https://doi.org/10.1097/00005373-199312000-00007

View Full Paper

Ask AI

Bookmark

Implication

Multicenter cohort study reveals severe early post-injury lymphopenia in major trauma patients, indicating that profound T-cell depletion correlates with subsequent infection and mortality risk.

Lymphocyte Subset Responses to Trauma and Sepsis

Key Points

Discussion

Implication

Cite This Study

Lymphocyte Subset Responses to Trauma and Sepsis

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider