Key result
An increased AST/ALT ratio was independently associated with a higher risk of all-cause mortality (HR 1.37) and cardiovascular mortality (HR 1.32) in Chinese patients with hypertension.
Why the study?
Previous studies linked an increased AST/ALT ratio to cardiovascular disease, but its relationship with all-cause and cardiovascular mortality in patients with hypertension required evaluation.
Does an increased AST/ALT ratio predict all-cause and cardiovascular mortality in Chinese patients with hypertension?
Population
14,220 Chinese hypertensive patients
Comparison
Higher AST/ALT ratio tertiles vs lowest tertile (Tertile 1)
Design
Cohort study
Follow-up
Average of 1.7 years
Authors
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May inform mortality risk stratification in hypertension; hypothesis-generating and requires prospective validation before clinical adoption.
Cohort (n=14,220)
Yes
Does an increased AST/ALT ratio predict all-cause and cardiovascular mortality in Chinese patients with hypertension?
Hazard Ratio: 1.37 (95% CI 1.15–1.63)
p-value: p=<0.001
An increased AST/ALT ratio is an independent predictor of all-cause and cardiovascular mortality in Chinese patients with hypertension.
Liu et al. (2021) conducted a cohort in Hypertension (n=14,220). AST/ALT ratio vs. Low AST/ALT ratio was evaluated on All-cause mortality (HR 1.37, 95% CI 1.15-1.63, p=<0.001). An increased AST/ALT ratio was independently associated with a higher risk of all-cause mortality (HR 1.37) and cardiovascular mortality (HR 1.32) in Chinese patients with hypertension.
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