Key result
Waist circumference remained a significant predictor of coronary artery calcification beyond traditional risk factors and plasma adipokines (Tobit regression ratio 1.69, P<0.001).
Why the study?
Does waist circumference predict coronary artery calcification beyond traditional risk factors and plasma adipokines in asymptomatic individuals?
Cross-Sectional (n=1,285)
Yes
Does waist circumference predict coronary artery calcification beyond traditional risk factors and plasma adipokines in asymptomatic individuals?
Effect estimate: Tobit regression ratio 1.69
p-value: p=< 0.001
Waist circumference remains a significant predictor of subclinical atherosclerosis beyond traditional risk factors and plasma adipokines, underscoring its importance in cardiovascular risk assessment.
Waist circumference may enhance CAC risk stratification beyond adipokines; leaves open prospective validation and clinical utility.
OBJECTIVE: The association of plasma adipokines beyond waist circumference (WC) with coronary artery calcification (CAC), a measure of subclinical atherosclerosis, is unknown. DESIGN AND METHODS: Asymptomatic Caucasian individuals from two community-based cross-sectional studies (n = 1,285) were examined and multivariate analysis of traditional risk factors was performed, then WC and adipokines (adiponectin and leptin) were added. Incremental value of each was tested with likelihood ratio testing. RESULTS: Beyond traditional risk factors, WC (Tobit regression ratio 1.69, P < 0.001) and plasma leptin (1.57, P < 0.001) but not plasma adiponectin (P = 0.75) were independently associated with CAC. In nested models, neither adiponectin (χ(2) = 0.76, P = 0.38) nor leptin (χ(2) = 1.32, P = 0.25) added value to WC beyond traditional risk factors, whereas WC added incremental value to adiponectin (χ(2) = 28.02, P < 0.0001) and leptin (χ(2) = 13.58, P = 0.0002). CONCLUSION: In the face of important biomarkers such as plasma adiponectin and leptin, WC remained a significant predictor of CAC beyond traditional risk factors underscoring the importance of WC measurement during cardiovascular risk assessment.
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Bose et al. (2013) conducted a cross-sectional in Subclinical atherosclerosis (n=1,285). Waist circumference vs. Traditional risk factors and plasma adipokines was evaluated on Coronary artery calcification (CAC) (Tobit regression ratio 1.69, p=< 0.001). Waist circumference remained a significant predictor of coronary artery calcification beyond traditional risk factors and plasma adipokines (Tobit regression ratio 1.69, P<0.001).
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