Key result
Lower plasma high-molecular-weight adiponectin concentrations were significantly associated with the presence, extent, and vulnerable characteristics of coronary plaques in patients with suspected coronary artery disease.
Cross-Sectional (n=394)
No
Odds Ratio: 0.74 (95% CI 0.57–0.95)
p-value: p=0.019
Lower plasma HMW adiponectin is independently associated with the presence, extent, and vulnerable characteristics of coronary plaques on CTA, suggesting its potential as a biomarker for high-risk coronary atherosclerosis.
Supports HMW adiponectin as a potential plaque biomarker on CTA; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND: Our group has previously reported that visceral adipose tissue (VAT) accumulation was associated with the extent and vulnerable characteristics of coronary plaques using coronary computed tomography angiography (CTA). An investigation of the associations between these coronary lesions with plasma adiponectin and leptin was performed. METHODS AND RESULTS: A total of 394 patients (220 men and 174 women) in the study were referred for CTA. Plain abdominal scanning was simultaneously performed to evaluate VAT areas. The median level of plasma high-molecular-weight (HMW) adiponectin in patients with CTA-based obstructive coronary artery disease was significantly lower than that in patients without (men: 1.45 vs. 1.88 µg/ml, P=0.002; women: 2.49 vs. 3.44 µg/ml, P<0.001). Multivariate analyses revealed that a lower HMW adiponectin concentration was significantly associated with the presence (men: P=0.019; women: P=0.018) and involved segment numbers (men: P=0.001; women: P=0.003) of coronary plaques. Furthermore, it was significantly related to coronary plaque with all 3 vulnerable characteristics of positive remodeling, low CT density (≤38 Hounsfield units), and adjacent spotty calcium (men: P=0.019; women: P=0.016). These associations were also observed with VAT areas, but not with plasma leptin concentrations, in both genders. CONCLUSIONS: Lower plasma HMW adiponectin is associated with the presence, extent, and vulnerable characteristics of coronary plaques assessed by CTA in both genders.
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Kunita et al. (2012) conducted a cross-sectional in Suspected coronary artery disease (n=394). Plasma high-molecular-weight adiponectin vs. Lower concentrations was evaluated on Presence of coronary plaques (per 1.00 μg/ml increase in HMW adiponectin, men) (OR 0.74, 95% CI 0.57-0.95, p=0.019). Lower plasma high-molecular-weight adiponectin concentrations were significantly associated with the presence, extent, and vulnerable characteristics of coronary plaques in patients with suspected coronary artery disease.