Key result
Wine pomace product supplementation in hypertensive or diabetic rats reduced wall aortic thickness, cross-sectional area, and wall/lumen ratio, decreased ROS, and increased eNOS activation.
Why the study?
Vascular remodeling in hypertension and diabetes involves inflammation and oxidative stress, which wine pomace products may attenuate via polyphenols.
Does wine pomace product supplementation improve morphometric parameters of the arterial wall in spontaneously hypertensive and streptozotocin-diabetic rats?
Does wine pomace product supplementation improve morphometric parameters of the arterial wall in spontaneously hypertensive and streptozotocin-diabetic rats?
Wine pomace product supplementation exhibits a protective role against endothelial dysfunction and vascular remodeling in hypertensive and diabetic rat models.
Wine pomace may protect arterial walls in hypertensive diabetic rat models; hypothesis-generating for human endothelial trials.
Vascular remodeling in hypertension and diabetes is characterized by a low-grade inflammation of the arterial wall and enhanced oxidative stress. Wine pomace products attenuate hyperglycemia and hypertension through reduction of oxidative stress and inflammation by their polyphenol composition. The aim of the study was to assess the influence of the wine pomace product (WP) on morphometric parameters of the arterial wall in spontaneously hypertensive rats (SHRs) and streptozotocin-diabetic rats (STZ). Oxidative stress was also evaluated by determination of radical oxygen species (ROS) and endothelial nitric oxide synthase (eNOS) activation in thoracic aortas. Wine pomace reduces wall aortic thickness, cross sectional area and wall/lumen ratio, and decreases ROS and increases eNOS activation. In summary, the supplementation of hypertensive or diabetic rats with the wine pomace product exhibits a protective role against the endothelial dysfunction and vascular remodeling.
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Gerardi et al. (2020) studied Hypertension and diabetes. Wine pomace product (WP) was evaluated on Morphometric parameters of the arterial wall, ROS, and eNOS activation. Wine pomace product supplementation in hypertensive or diabetic rats reduced wall aortic thickness, cross-sectional area, and wall/lumen ratio, decreased ROS, and increased eNOS activation.
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