Key result
Detection of human coronavirus alone or in co-infection with rhinovirus C was independently associated with an increased risk of PICU admission in young children hospitalized for ALRI.
Why the study?
The study aimed to assess the profile of respiratory viruses in young children hospitalized for ALRI and its association with disease severity defined as need for PICU admission.
Cohort (n=236)
No
In young children hospitalized with acute lower respiratory tract infection, detection of human coronavirus alone or co-infected with rhinovirus C is an independent risk factor for PICU admission.
Answers are grounded in this paper and cite their sources.
May aid PICU risk stratification in pediatric ALRTI; hypothesis-generating and requires prospective validation before practice change.
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Matsuno et al. (2019) conducted a cohort in Acute lower respiratory tract infection (ALRI) (n=236). Human coronavirus (HCoV) alone or in co-infection with rhinovirus C (RV-C) vs. Absence of HCoV was evaluated on Need for pediatric intensive care unit (PICU) admission (adjusted RR 2.18, 95% CI 1.15-4.15). Detection of human coronavirus alone or in co-infection with rhinovirus C was independently associated with an increased risk of PICU admission in young children hospitalized for ALRI.
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