What is the clinical evidence from this study?

Study design: Observational. Population: Healthy (n=10). Intervention: Orthostatic challenge (standing up and sitting down) vs. Resting state (seated). Primary outcome: Topological changes in the cardiorespiratory-cerebrovascular network (linear and nonlinear interdependencies).

March 2, 2021Frontiers in PhysiologyOpen Access

Two-Tiered Response of Cardiorespiratory-Cerebrovascular Network to Orthostatic Challenge

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Key result

Orthostatic challenge induced a marked weakening of nonlinear interdependencies between cardiac, respiratory, and cerebrovascular dynamics, while linear dependencies showed non-significant changes.

Why the study?

Dynamic interdependencies across physiological systems mediate regulatory responses to orthostatic stress, but the responsiveness of cardiorespiratory-cerebrovascular networks to postural changes needed evaluation.

Does orthostatic challenge alter cardiorespiratory-cerebrovascular network interdependencies in healthy young adults?

Population

Ten young healthy adults

Comparison

Resting state vs 1-min stand-up vs 1-min sit-down period

Design

Physiological interdependency study

Authors

PMPéter Mukli ZNZoltán Nagy FRFrigyes Sámuel Rácz

Discussion

Member takes

Overview

May signal transient network vulnerability during orthostasis; leaves open relevance to syncope or autonomic disorders.

Key Points

To evaluate the responsiveness and dynamic network interdependencies between cardiac, respiratory, and cerebrovascular systems during orthostatic postural transitions.
Monitored continuous arterial blood pressure, breath-to-breath intervals, cerebral blood flow velocity via transcranial Doppler sonography, and total hemoglobin via near-infrared spectroscopy in 10 young healthy adults.
Conducted a protocol comprising a 30-minute baseline rest, a 1-minute standing challenge, and a 1-minute sitting recovery.
Reconstructed physiological interaction networks using Pearson correlation for linear dependencies and mutual information for nonlinear dependencies after regressing arterial blood pressure from cerebrovascular signals.
Standing up induced a marked weakening in the interdependencies across cardiac, respiratory, and cerebrovascular dynamics that persisted through the subsequent sit-down period.
The observed network dissolution was primarily driven by a significant attenuation of nonlinear coupling rather than linear interactions.

Study Design

Type

Observational (n=10)

Multicenter

Structured PICO

Does orthostatic challenge alter cardiorespiratory-cerebrovascular network interdependencies in healthy young adults?

Population

10 healthy young adults free of cardiovascular or neurological diseases underwent orthostatic challenge to evaluate cardiorespiratory-cerebrovascular network responses.

Exposure

Orthostatic challenge consisting of a 1-minute stand-up and 1-minute sit-down period.

Comparator

30-minute resting state.

Outcome

Responsiveness of the cardiorespiratory-cerebrovascular networks by capturing linear and nonlinear interdependencies to postural changes.surrogate

Orthostatic stress induces topological changes and dissolution of nonlinear networks in cardiorespiratory-cerebrovascular interactions, highlighting the sensitivity of homeostatic mechanisms to physiological perturbations.

Limitations

Small sample size
Short time spent in the perturbated states (1 minute)
Exclusion of the very early phase of the postural challenge from analysis due to transient motion artifacts
Lack of electrophysiological data (e.g., EEG) to disentangle subsystems with respect to brain activity changes

Cite This Study

Mukli et al. (2021) conducted an observational in Healthy (n=10). Orthostatic challenge (standing up and sitting down) vs. Resting state (seated) was evaluated on Topological changes in the cardiorespiratory-cerebrovascular network (linear and nonlinear interdependencies). Orthostatic challenge induced a marked weakening of nonlinear interdependencies between cardiac, respiratory, and cerebrovascular dynamics, while linear dependencies showed non-significant changes.

synapsesocial.com/papers/6a9a125bf9da1bc1819e4064 https://doi.org/10.3389/fphys.2021.622569

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March 2, 2021Frontiers in PhysiologyOpen Access

Two-Tiered Response of Cardiorespiratory-Cerebrovascular Network to Orthostatic Challenge

View Full Paper

Ask AI

Bookmark

Key result

Orthostatic challenge induced a marked weakening of nonlinear interdependencies between cardiac, respiratory, and cerebrovascular dynamics, while linear dependencies showed non-significant changes.

Why the study?

Does orthostatic challenge alter cardiorespiratory-cerebrovascular network interdependencies in healthy young adults?

Population

Ten young healthy adults

Comparison

Resting state vs 1-min stand-up vs 1-min sit-down period

Design

Physiological interdependency study

Authors

PMPéter Mukli ZNZoltán Nagy FRFrigyes Sámuel Rácz

Discussion

Member takes

Overview

May signal transient network vulnerability during orthostasis; leaves open relevance to syncope or autonomic disorders.

Key Points

To evaluate the responsiveness and dynamic network interdependencies between cardiac, respiratory, and cerebrovascular systems during orthostatic postural transitions.
Monitored continuous arterial blood pressure, breath-to-breath intervals, cerebral blood flow velocity via transcranial Doppler sonography, and total hemoglobin via near-infrared spectroscopy in 10 young healthy adults.
Conducted a protocol comprising a 30-minute baseline rest, a 1-minute standing challenge, and a 1-minute sitting recovery.
Reconstructed physiological interaction networks using Pearson correlation for linear dependencies and mutual information for nonlinear dependencies after regressing arterial blood pressure from cerebrovascular signals.
Standing up induced a marked weakening in the interdependencies across cardiac, respiratory, and cerebrovascular dynamics that persisted through the subsequent sit-down period.
The observed network dissolution was primarily driven by a significant attenuation of nonlinear coupling rather than linear interactions.

Study Design

Type

Observational (n=10)

Multicenter

Structured PICO

Does orthostatic challenge alter cardiorespiratory-cerebrovascular network interdependencies in healthy young adults?

Population

10 healthy young adults free of cardiovascular or neurological diseases underwent orthostatic challenge to evaluate cardiorespiratory-cerebrovascular network responses.

Exposure

Orthostatic challenge consisting of a 1-minute stand-up and 1-minute sit-down period.

Comparator

30-minute resting state.

Outcome

Responsiveness of the cardiorespiratory-cerebrovascular networks by capturing linear and nonlinear interdependencies to postural changes.surrogate

Limitations

Small sample size
Short time spent in the perturbated states (1 minute)
Exclusion of the very early phase of the postural challenge from analysis due to transient motion artifacts
Lack of electrophysiological data (e.g., EEG) to disentangle subsystems with respect to brain activity changes

Cite This Study

synapsesocial.com/papers/6a9a125bf9da1bc1819e4064 https://doi.org/10.3389/fphys.2021.622569

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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