October 13, 2017Journal of Applied Physiology

Dynamic AP changes explained a substantial proportion of the variation in faster CBF fluctuations (partial R2 = 0.75, standardized β = 0.83, P < 0.01), whereas CO2 explained the largest portion of the variation in slow fluctuations (partial R2 = 0.43, β = 0.51, P < 0.01).

View Full Paper

Ask AI

Bookmark

Population

14 young volunteers

Design

Other

Authors

HYHisao YoshidaKyoto University JHJason W. HamnerSpaulding Rehabilitation Hospital KIKeita IshibashiChiba University

Discussion

Member takes

Overview

Supports frequency-specific CBF regulation by AP and CO2; hypothesis-generating for monitoring but should not yet change practice.

Structured PICO

Population

14 young volunteers

Intervention

Oscillatory lower body pressure (LBP) (±20 mmHg at 0.01 and 0.06 Hz) at three static levels (−20, 0, and +20 mmHg)

Outcome

Relation of fluctuations in cerebral blood flow (CBF) to those in arterial pressure (AP), cardiac output, and CO2surrogate

Fluctuations in blood pressure drive faster fluctuations in cerebral blood flow, while CO2 and cardiac output determine the magnitude of slow fluctuations, with slow blood pressure fluctuations becoming apparent only during pronounced central volume shifts.

Cite This Study

Yoshida et al. (2017) studied this question.

synapsesocial.com/papers/6a86bb67385344fed8cb8ab1 https://doi.org/10.1152/japplphysiol.00700.2017

View Full Paper

Ask AI

Bookmark

October 13, 2017Journal of Applied Physiology

Dynamic AP changes explained a substantial proportion of the variation in faster CBF fluctuations (partial R2 = 0.75, standardized β = 0.83, P < 0.01), whereas CO2 explained the largest portion of the variation in slow fluctuations (partial R2 = 0.43, β = 0.51, P < 0.01).

View Full Paper

Ask AI

Bookmark

Population

14 young volunteers

Design

Other

Authors

HYHisao YoshidaKyoto University JHJason W. HamnerSpaulding Rehabilitation Hospital KIKeita IshibashiChiba University

Discussion

Member takes

Overview

Supports frequency-specific CBF regulation by AP and CO2; hypothesis-generating for monitoring but should not yet change practice.

Structured PICO

Population

14 young volunteers

Intervention

Oscillatory lower body pressure (LBP) (±20 mmHg at 0.01 and 0.06 Hz) at three static levels (−20, 0, and +20 mmHg)

Outcome

Relation of fluctuations in cerebral blood flow (CBF) to those in arterial pressure (AP), cardiac output, and CO2surrogate

Cite This Study

Yoshida et al. (2017) studied this question.

synapsesocial.com/papers/6a86bb67385344fed8cb8ab1 https://doi.org/10.1152/japplphysiol.00700.2017

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark