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November 1, 2017Physiological ReportsOpen Access

Diminished dynamic cerebral autoregulatory capacity with forced oscillations in mean arterial pressure with elevated cardiorespiratory fitness

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Key result

Elevated cardiorespiratory fitness in endurance athletes was associated with a delayed onset of cerebral autoregulation after sit-to-stand compared to controls (3.1 vs. 1.5 sec; P=0.03).

Why the study?

Does elevated cardiorespiratory fitness alter dynamic cerebral autoregulatory capacity during changes in mean arterial pressure in males?

Population

27 males, comprising 19 endurance athletes and 8 recreational controls

Comparison

Elevated cardiorespiratory fitness vs Recreational controls

Design

Cross-sectional

Authors

LLLawrence LabrecqueKRKevan RahimalySISarah Imhoff

Discussion

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Member takes

Overview

May warrant caution in orthostatic assessments of athletes; leaves open clinical relevance of delayed autoregulation.

Study Design

Type

Cross-Sectional (n=27)

Structured PICO

Does elevated cardiorespiratory fitness alter dynamic cerebral autoregulatory capacity during changes in mean arterial pressure in males?

P
Population
27 participants, comprising 19 male endurance athletes and 8 controls, evaluated for dynamic cerebral autoregulatory capacity during changes in mean arterial pressure.
E
Exposure
Elevated cardiorespiratory fitness (endurance athletes)
C
Comparator
Recreational controls
O
Outcome
Dynamic cerebral autoregulatory capacity measured via onset of regulation, rate of regulation, and transfer function analysis (TFA) of MAP and MCAv responsessurrogate

Main Result

Absolute Event Rate: 3.1% vs 1.5%

p-value: p=0.03

Individuals with elevated cardiorespiratory fitness exhibit an attenuated capability of the cerebral vasculature to counter rapid and large changes in mean arterial pressure, despite intact responses to spontaneous oscillations.

Cite This Study

Labrecque et al. (2017) conducted a cross-sectional in Elevated cardiorespiratory fitness (n=27). Elevated cardiorespiratory fitness (endurance athletes) vs. Recreational controls was evaluated on Onset of regulation (time delay before an increase in middle cerebral artery conductance) after sit-to-stand (p=0.03). Elevated cardiorespiratory fitness in endurance athletes was associated with a delayed onset of cerebral autoregulation after sit-to-stand compared to controls (3.1 vs. 1.5 sec; P=0.03).

synapsesocial.com/papers/6a732ae59ac491c14dc3f7bbhttps://doi.org/10.14814/phy2.13486
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Also Consider

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