Key result
Paxillin was widely expressed in non-muscle and multinuclear striated muscle tissues, whereas Hic-5 expression was restricted mainly to mononuclear smooth muscle.
Tissue-specific patterns remain preclinical; leaves open distinct roles in muscle homeostasis and disease.
The LIM domain is a protein-protein interaction motif critically involved in a variety of fundamental biological processes, including cytoskeletal organization, cell lineage specification, and organ development. In this study we examined the expression of the LIM proteins paxillin and Hic-5 in adult human tissues by immunohistochemistry and immunoblotting. Paxillin expression was widespread and observed both in non-muscle and muscle tissues. Of the latter, paxillin was mainly expressed in multinuclear striated muscle. In contrast, Hic-5 showed restricted expression and was expressed in muscle tissues, mainly in mononuclear smooth muscle. Taken together with previous findings, it appears likely that the counterbalance between paxillin and Hic-5 may be deeply involved in muscle differentiation.
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Yuminamochi et al. (2003) studied this question. Paxillin and Hic-5 expression was evaluated on Tissue expression patterns. Paxillin was widely expressed in non-muscle and multinuclear striated muscle tissues, whereas Hic-5 expression was restricted mainly to mononuclear smooth muscle.
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