Key result
Long-term regional citrate anticoagulation for high-flux haemodialysis in a patient with heparin-induced thrombocytopenia type II achieved excellent solute removal (KT/V 1.52-1.98) over 9 months.
Why the study?
Does long-term regional citrate anticoagulation provide effective anticoagulation and solute removal in a patient with heparin-induced thrombocytopenia type II undergoing high-flux haemodialysis?
Case Report (n=1)
Does long-term regional citrate anticoagulation provide effective anticoagulation and solute removal in a patient with heparin-induced thrombocytopenia type II undergoing high-flux haemodialysis?
Long-term regional citrate anticoagulation is feasible and effective for high-flux hemodialysis in patients with heparin-induced thrombocytopenia type II.
Single-case success with regional citrate anticoagulation in HIT II; leaves open need for prospective trials before clinical adoption.
For the first time, long-term use of regional citrate anticoagulation for high-flux haemodialysis is reported in a patient with heparin-induced thrombocytopenia type II. A simple, flow-independent, citrate infusion protocol allowed efficient anticoagulation. Excellent solute removal, indicated by KT/V values of 1.52 to 1.98, was achieved. Electrolyte and acid-base balance as well as calcium homeostasis were well controlled over a period of 9 months.
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Unver et al. (2002) conducted a case report in Heparin-induced thrombocytopenia type II requiring high-flux haemodialysis (n=1). Regional citrate anticoagulation was evaluated on Efficacy of anticoagulation, solute removal, electrolyte/acid-base balance, and calcium homeostasis. Long-term regional citrate anticoagulation for high-flux haemodialysis in a patient with heparin-induced thrombocytopenia type II achieved excellent solute removal (KT/V 1.52-1.98) over 9 months.
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