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BENEDICT, R. G., SCHMIDT, W. H., AND COGHILL, R. D. 1946 The stability of penicillin in aqueous solution. J. Bacteriol., 51, 291-292. CLARKE, H. T., JOHNSON, J. R., AND ROBINSON, R. 1949a The chemistry of penicillin. Princeton University Press, Princeton, N. J., p. 96. CLARKE, H. T., JOHNSON, J. R., AND ROBINSON, R. 1949b The chemistry of penicillin. Princeton University Press, Princeton, N. J., p. 672. CORSE, J. W., JONES, R. G., SOPER, Q. F., WHITEHEAD, C. W., AND BEHRENS, 0. K. 1948 Biosynthesis of penicillins V. substituted phenylacetic acid derivatives as penicillin precursors. J. Am. Chem. Soc., 70, 2837-2843. EAGLE, H. 1947a The therapeutic activity of penicillins F, G, K, and X in experimental infections with Pneumococcus Type I and Streptococcus pyogenes. J. Exp. Med., 85, 175-186. EAGLE, H. 1947b The varying blood levels afforded by penicillins F, G, K and X in rabbits and man. J. Exp. Med., 85, 163-173. GAILEY, F. B., STEFANIAK, J. J., OLSON, B. H., AND JOHNSON, M. J. 1946 A comparison of penicillin producing strains of Penicillium notatum-chrysogenum. J. Bacteriol., 52, 129-140. GILMAN, H., AND BLATT, A. H. 1948 Organic synthesis, collected volume I. John Wiley and Sons, Inc., New York, N. Y., pp. 52-53. HEWITr, W. L., AND PIrrMAN, M. 1946 Antibacterial action of penicillin, penicillin X, and streptomycin on Hemophilus influenzae. U. S. Public Health Repts., 61, 768-778. JARVIS, F. G., AND JOHNSON, M. J. 1947 The role of the constituents of synthetic media for penicillin production. J. Am. Chem. Soc., 69, 3010-3017. KARNOVSKY, M. L., AND JOHNSON, M. J. 1949 Filter paper chromatography of penicillin broths. Anal. Chem. 21, 1125-1132. THORN, J. A., AND JOhINSON, M. J. 1950 Precursors fo aliphatic penicillins. J. Am. Chem. Soc., 72, 2052-2058
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Joseph L. Stone (1953) studied this question.
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