Key result
Treatment of preconditioned rats with a Treg cell-depleting antibody resulted in a larger myocardial infarct size compared with IgG injection (p < 0.001).
Why the study?
Does targeted deletion of regulatory T cells attenuate the protective effects of myocardial ischemic preconditioning in rats?
Does targeted deletion of regulatory T cells attenuate the protective effects of myocardial ischemic preconditioning in rats?
p-value: p=<0.001
Regulatory T cells contribute significantly to the cardioprotective and anti-inflammatory effects of myocardial ischemic preconditioning in a rat model.
Treg depletion enlarges infarcts despite preconditioning in rats; hypothesis-generating for human relevance, should not change practice.
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Ke et al. (2015) studied Myocardial ischemia-reperfusion injury. Treg cell-depleting antibody vs. Normal rat immunoglobulin (IgG) was evaluated on Myocardial infarct size (p=<0.001). Treatment of preconditioned rats with a Treg cell-depleting antibody resulted in a larger myocardial infarct size compared with IgG injection (p < 0.001).
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