Key result
Having two or more complicating factors in the MAFLD definition was associated with a higher prevalence of progressive MAFLD (32-44%) and had a 97.4% negative predictive value for UpMAFLD.
Why the study?
The authors aimed to establish a method to identify patients with fatty liver who are at high risk for a progressive phenotype.
Does the presence of multiple criteria in the definition of metabolic dysfunction-associated fatty liver identify patients at high risk for significant fibrosis?
Comparison
Patients classified by number of MAFLD definition criteria
Design
Two-cohort study
Authors
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May aid noninvasive risk stratification in MAFLD; leaves open whether it improves outcomes before prospective validation.
Cohort (n=401)
Does the presence of multiple criteria in the definition of metabolic dysfunction-associated fatty liver identify patients at high risk for significant fibrosis?
Having two or more complicating factors in the MAFLD definition provides a high negative predictive value, helping to identify which patients require further evaluation for liver fibrosis.
Kakisaka et al. (2023) conducted a cohort in Metabolic dysfunction-associated fatty liver (MAFLD) (n=401). Two or more complicating factors in the MAFLD definition vs. Fewer than two complicating factors was evaluated on Progressive phenotype of MAFLD (BpMAFLD or UpMAFLD). Having two or more complicating factors in the MAFLD definition was associated with a higher prevalence of progressive MAFLD (32-44%) and had a 97.4% negative predictive value for UpMAFLD.
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