Key result
Serum vaspin level accurately predicted the amelioration of fatty liver and metabolic disturbance in patients with severe obesity after laparoscopic vertical banded gastroplasty (AUC 0.871).
Why the study?
Does serum vaspin level predict the amelioration of fatty liver and metabolic disturbance in patients with severe obesity after laparoscopic vertical banded gastroplasty?
Cohort (n=164)
Yes
Does serum vaspin level predict the amelioration of fatty liver and metabolic disturbance in patients with severe obesity after laparoscopic vertical banded gastroplasty?
Effect estimate: AUC 0.871 (95% CI 0.810-0.931)
p-value: p=<0.001
Serum vaspin level ≤0.9 is a strong predictor for the amelioration of fatty liver and metabolic disturbances following laparoscopic vertical banded gastroplasty in severely obese patients.
Serum vaspin may predict post-gastroplasty metabolic improvement in obesity; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND: This study is all about predicting the value of serum vaspin level in the amelioration of fatty liver and metabolic disturbance in patients with severe obesity after laparoscopic vertical banded gastroplasty (LVBG). METHODS: A total of 164 patients (from January 2012 to May 2015) with severe obesity were chosen and performed LVBG. Enzyme-linked immunosorbent assay was performed to detect the serum vaspin level. The patients were given a biochemical automatic analyzer to measure the biochemical indicators. Homeostasis model assessment (HOMA) helps in the calculation of fasting insulin level (FINS) and insulin resistance (IR). The changes in fatty liver were examined by computed tomography (CT). Receiver operating characteristic curve is used to increase the predictive value of serum vaspin level in the amelioration of liver function and disturbances in the metabolism. RESULTS: Weight, BMI, waist circumference, serum vaspin level, and triglyceride (TG) decreased, but CT value of liver increased at 4th, 7th, and 12th month after surgery. After the 7th and 12th month period of surgery, the alanine aminotransferase, aspartate aminotransferase, FINS, and HOMA-IR reduced in the patients (P <.005). The area under ROC curve (AUC) is about 0.871 ± 0.031 with 95%CI of 0.810-0.931 (P <.001). The sensitivity, specificity, and accuracy of serum vaspin level ≤0.9 were 87.80%, 78.05%, and 83.28%, respectively. BMI, FINS, and serum vaspin level ≤0.9 were the influencing factors of the amelioration of fatty liver and metabolic disturbance. CONCLUSION: This study proves that the serum vaspin level serves as a predictive indicator in the amelioration of fatty liver and metabolic disturbance in patients with severe obesity after LVBG.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2017) conducted a cohort in Severe obesity (n=164). Serum vaspin level was evaluated on Predictive value for amelioration of fatty liver and metabolic disturbance (AUC 0.871, 95% CI 0.810-0.931, p=<0.001). Serum vaspin level accurately predicted the amelioration of fatty liver and metabolic disturbance in patients with severe obesity after laparoscopic vertical banded gastroplasty (AUC 0.871).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: