Key result
Early stent thrombosis occurred in 4.5% of patients after primary stenting for STEMI, with symptom onset occurring predominantly during night hours (00:00-06:00) and winter months.
Why the study?
What is the circadian, weekly, and seasonal variation in the occurrence of early stent thrombosis after primary PCI for STEMI?
Cohort (n=1,960)
What is the circadian, weekly, and seasonal variation in the occurrence of early stent thrombosis after primary PCI for STEMI?
Early stent thrombosis after primary PCI for STEMI exhibits circadian and seasonal variation, occurring more frequently at night and during winter months.
Night and winter clustering of early stent thrombosis after STEMI PCI is hypothesis-generating; leaves open whether timing-specific strategies merit prospective testing.
One of the major concerns remaining in the treatment with stenting is the occurrence of stent thrombosis (ST). We reviewed 1960 consecutive patients (mean age 56 ± 11.6 years, 84.6% males) treated with primary coronary stenting for ST elevation myocardial infarction between 2003 and 2008. All clinical, angiographic, and follow-up data were retrospectively collected. The data when the patient had angina pectoris was obtained from medical record. Early ST was observed in 89 (4.5%) patients. We identified 86 patients with early ST and known date and time of symptom onset. In these patients (mean age 59.2 ± 13.9, 83.7% males), symptoms occurred mostly at night time (00.00-6.00 am) and during winter months but the day of the week effect was not presence. In conclusion, occurrences of early ST throughout the week were equally distributed, but early ST was more likely to occur in the winter months and night hours.
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Işık et al. (2012) conducted a cohort in ST elevation myocardial infarction (n=1,960). Circadian, weekly, and seasonal timing was evaluated on Early stent thrombosis. Early stent thrombosis occurred in 4.5% of patients after primary stenting for STEMI, with symptom onset occurring predominantly during night hours (00:00-06:00) and winter months.
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