Frequency of early stent thrombosis in patients presenting with STEMI Undergoing Primary Percutaneous Coronary Intervention (PPCI) at a Tertiary Care Hospital.

Q: What is the clinical evidence from this study?

Study design: Observational. Population: ST-elevation myocardial infarction (STEMI) (n=234). Intervention: Primary percutaneous coronary intervention (PPCI). Primary outcome: Early stent thrombosis within 30 days after PPCI.

Q: What does this research mean for the field?

Early stent thrombosis occurs in 5.6% of STEMI patients within 30 days of undergoing primary percutaneous coronary intervention and is significantly associated with culprit vessel involvement. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

Muhammad Hamad; Furrakh Maqbool; Imran Rasheed; Rabia Khalid; Muneeb Ur Rehman; Sayyed Abbas Rasool

doi:10.29309/tpmj/2026.33.10.10779

October 2, 2026The Professional Medical JournalOpen Access

Frequency of early stent thrombosis in patients presenting with STEMI Undergoing Primary Percutaneous Coronary Intervention (PPCI) at a Tertiary Care Hospital.

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Key result

Early stent thrombosis occurs in ~6% of STEMI patients undergoing primary PCI, linked to culprit vessel.

n=234

Why the study?

The frequency of early stent thrombosis in patients presenting with STEMI undergoing PPCI at a tertiary care hospital needed to be determined.

Key Points

To determine the frequency of early stent thrombosis in patients presenting with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.
Case series of 234 patients aged 18–60 years presenting with STEMI who underwent PPCI at Sheikh Zayed Hospital, Rahim Yar Khan between October 2025 and March 2026.
Participants were enrolled using non-probability consecutive sampling, and demographic, clinical, biochemical, angiographic, and procedural variables were recorded.
Patients were prospectively followed for 30 days after PPCI to detect the occurrence of early stent thrombosis.
Early stent thrombosis occurred in 13 of 234 patients (5.6%) within 30 days post-PPCI, with chest pain representing the most frequent clinical presentation (3.4%).
Culprit vessel involvement was statistically significantly associated with early stent thrombosis (p=0.028), occurring in 11.8% (8/68) of right coronary artery interventions compared to 3.3% (4/122) in the left anterior descending artery and 2.3% (1/44) in the left circumflex artery.
No statistically significant associations were identified between early stent thrombosis and age (p=1.000), gender (p=1.000), diabetes mellitus (p=0.214), hypertension (p=0.310), dyslipidemia (p=0.188), smoking (p=0.923), or stent type (p=0.658).

Study Design

Type

Observational (n=234)

Multicenter

No

Structured PICO

P

Population

234 adults aged 18-60 years (mean age 54.9 years, 21.4% female) presenting with STEMI and undergoing primary PCI, free of prior stenting in the culprit vessel, followed for 30 days.

E

Exposure

Primary percutaneous coronary intervention (PPCI) with standard stenting procedures (95.7% drug-eluting stent, 4.3% plain balloon angioplasty) and post-dilation with non-compliant balloons in all cases, preceded by 300 mg soluble aspirin, 600 mg clopidogrel, and 70-100 units/kg unfractionated heparin.

O

Outcome

Early stent thrombosis (occurring between 24 hours and 30 days following PPCI), confirmed by coronary angiography showing complete occlusion in the stented segment with angiographic presence of thrombus.hard clinical

In this single-center Pakistani cohort of STEMI patients undergoing primary PCI, early stent thrombosis occurred in 5.6% of cases within 30 days and was significantly associated with culprit vessel location, particularly the right coronary artery.

Limitations

Single-center study limiting generalizability to the broader population
Relatively small sample size resulting in limited statistical power to detect associations with clinical variables
Short follow-up period of 30 days with no assessment of late or very late stent thrombosis
Lack of assessment for medication adherence, platelet reactivity testing, thrombus burden grading, and intravascular imaging (IVUS or OCT)
Single-center study limiting generalizability to the general population
Relatively small sample size limiting statistical power to investigate associations between some clinical variables and early stent thrombosis
Follow-up period was only 30 days with no assessment of late or very late stent thrombosis
No assessment of medication adherence, platelet reactivity testing, thrombus burden grading, or detailed procedural imaging modalities (IVUS or OCT)

Implication

Culprit vessel association with early stent thrombosis post-PPCI is hypothesis-generating; larger prospective studies needed before practice implications.

Abstract

Objective: To determine the frequency of early stent thrombosis in patients presenting with STEMI undergoing PPCI. Study Design: Case Series. Setting: Department of Cardiology at Sheikh Zayed Hospital, Rahim Yar Khan. Period: October 2025 to March 2026. Methods: The patients were selected using non-probability consecutive sampling and a total of 234 patients with an age range of 18-60 years and STEMI who underwent PPCI were included in the study. Demographic, clinical, biochemical, angiographic, and procedural characteristics were recorded. Patients were followed for 30 days after PPCI for the development of early stent thrombosis. SPSS version 23 was used for data analysis. Results: The mean age of the patients was 54.9 ± 9.2 years, and 78.6% were male patients. Common comorbidities were dyslipidemia (70.1%), hypertension (47.9%), and diabetes mellitus (44.9%). There were 13 (5.6%) patients with early stent thrombosis. The commonest presenting symptom was chest pain. The involvement of the culprit vessel was statistically significant (p=0.028) in association with early stent thrombosis, and there were no other significant associations with the demographic and clinical variables. Conclusion: Early stent thrombosis is still a clinically relevant complication following PPCI in STEMI patients. Strategies to minimize thrombotic complications and enhance patient outcomes may include careful procedural planning, aggressive management of risk factors, and monitoring to ensure proper post-procedural care.

Discussion

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Cite This Study

Hamad et al. (2026) conducted an observational in ST-elevation myocardial infarction (STEMI) (n=234). Primary percutaneous coronary intervention (PPCI) was evaluated on Early stent thrombosis within 30 days after PPCI. Primary percutaneous coronary intervention in STEMI patients resulted in a 5.6% frequency of early stent thrombosis within 30 days, significantly associated with culprit vessel involvement (p=0.028).

synapsesocial.com/papers/6ae28e0ecbadf70daf6c3fff https://doi.org/10.29309/tpmj/2026.33.10.10779

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Bookmark

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Frequency of early stent thrombosis in patients presenting with STEMI Undergoing Primary Percutaneous Coronary Intervention (PPCI) at a Tertiary Care Hospital.

Key Points

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Frequency of early stent thrombosis in patients presenting with STEMI Undergoing Primary Percutaneous Coronary Intervention (PPCI) at a Tertiary Care Hospital.

Key Points

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

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